International Journal of Integrative Dental and Medical Sciences
type: channel
description: The International Journal of Integrative Dental and Medical Sciences (IJIDMS) is a distinguished, open-access journal committed to publishing innovative research and comprehensive reviews across various dental and medical disciplines. Our mission is to advance both scientific research and clinical practice in the dental and medical fields. IJIDMS welcomes contributions from a wide array of specialties, including but not limited to Dentistry, Oral and Maxillofacial Surgery, Periodontology, Orthodontics, Prosthodontics, General Medicine, Public Health, and Integrative Medicine. We invite researchers to submit their meticulously crafted studies, innovative topics, and recent advancements in the dental and medical fields. Submissions may include original research articles, clinical case reports, or detailed reviews. By fostering collaboration and the exchange of knowledge, IJIDMS strives to be a premier platform for showcasing groundbreaking research and promoting excellence in healthcare practices. All articles published in IJIDMS are freely accessible online immediately upon publication. We encourage researchers, academicians, healthcare professionals, and industry experts to contribute their work, advancing the field of dental and medical sciences. Journal Standards: Renowned editorial board with expertise from around the globe. Timely email alerts and updates on published content. Indexed in various respected databases and maintained by international publishers. Open access to all content, available to readers free of charge. Fast and seamless online manuscript submission process. Certificate of publication available upon request. No subscription fees; all papers are freely accessible upon publication. Rapid publishing process to ensure wide exposure for research. We invite you to contribute to International Journal of Integrative Dental and Medical Sciences (IJIDMS) and help us advance cutting-edge research and elevate standards of practice in the dental and medica…
publisher: Sujata Publications
language: en
publication name: International Journal of Integrative Dental and Medical Sciences
issn: 3049-4222
items: Single-Shade Universal Composites in Restorative Dentistry: A Review of Omnichroma
items: Aesthetic Rehabilitation with Direct Composite Veneering using single shade composite resin: A Case Report
items: Anterior Diastema Closure Using Frenectomy and Direct Composite Resin Restoration: A Case Report
items: MRI Evaluation of Different Types of Cerebral Metastases
items: Orthodontic Treatment and Its Impact on Oral Health–Related Quality of Life
items: Phytochemicals in Traditional Medicine: A Modern Approach to Evidence-Based Herbal Therapies
items: Comparative Evaluation of Analgesic, Anti-Inflammatory, and Antipyretic Activities of Morus alba and Pyrus pyrifolia
items: Transforming Oral Healthcare Through AI: A White Paper on SwaLife Oral Disease Diagnosis
items: Oxidative Stress and Reactive Oxygen Species in Tumor Initiation and Progression
items: The Emerging Role of Non-Coding RNAs in Carcinogenesis and Tumor Metastasis
items: Molecular Crosstalk Between Chronic Inflammation and Cancer Development
items: Oncogenic Signaling Pathways in Tumor Progression: An Update on PI3K/AKT/MTOR and MAPK axis
items: Epigenetic Alterations in Carcinogenesis: Role of DNA Methylation and Histone Modifications
items: Obesity-Linked Metabolic Alterations as Drivers of Carcinogenesis
items: Dietary Polyphenols and their Protective Role Against Carcinogenesis
items: Minimally Invasive Techniques in Oral and Maxillofacial Surgery
items: Advances in Maxillofacial Trauma Management and Rehabilitation
items: Clinical Outcomes of Oral and Maxillofacial Surgical Interventions: A Retrospective Study
items: Oral Health Awareness and Its Role in Public Health Promotion
items: Innovations in Restorative Dentistry: Materials, Techniques, and Clinical Outcomes
items: Impact of Oral Hygiene Practices on Systemic Health Outcomes
items: Dental Caries and Periodontal Diseases: An Integrative Clinical Perspective
items: Advances in Preventive Dentistry: Clinical Strategies for Long-Term Oral Health
items: The Role of Oral Microbiota in Systemic Diseases: Bridging the gap between Dentistry and Medicine
items: Psychological Well-Being and Oral Health: The Role of Dentistry in Comprehensive Healthcare
items: Interdisciplinary Approaches to Managing Oral Cancer: Combining Dentistry, Oncology, and Surgery
items: Integrative Pain Management: Dental and Medical Strategies in the Treatment of Temporomandibular Joint Disorder
items: Advances in Dental Biomaterials: Bridging Dentistry and Medicine for Improved Patient Outcomes

Single-Shade Universal Composites in Restorative Dentistry: A Review of Omnichroma
type: item
description: The emergence of single-shade universal resin composites marks a paradigm shift in restorative dentistry, simplifying the complex and error-prone process of colour matching. OMNICHROMA (Tokuyama Dental) is the foremost product in this category, employing a sophisticated "Smart Chromatic Technology" based on structural colouration rather than traditional pigment inclusion. This comprehensive review synthesizes recent in vitro and clinical evidence, focusing on OMNICHROMA's unique mechanism, optical performance, clinical efficacy, and physical properties, including surface roughness and repair bond strength. Literature confirms OMNICHROMA’s superior blending effect, leading to excellent visual colour matching across the VITA classical range, often comparable to dedicated multi-shade composites. While instrumental colour measurements sometimes exceed perceptibility thresholds for specific optimal shades, the material's strong chameleon effect ensures high visual acceptability and patient satisfaction, confirming its clinical reliability in both anterior and posterior restorations. Furthermore, OMNICHROMA demonstrates comparable resistance to aging effects and successful repairability when appropriate surface conditioning is utilized, solidifying its position as a reliable, time-saving aesthetic solution.
subject: Articles
  topic: section
subject: OMNICHROMA, Tokuyama Dental, Restorative Dentistry
  topic: keywords
creator: Pradnya Bansode
creator: Sadashiv Gopinath Daokar
creator: Shruti Bajaj
rights: Copyright (c) 2026 International Journal of Integrative Dental and Medical Sciences https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-21
publication date: 2026-01-21
starting page: 20
ending page: 23
doi: 10.62896/ijidms.2.1.04

Aesthetic Rehabilitation with Direct Composite Veneering using single shade composite resin: A Case Report
type: item
description: Tooth wear is defined as the loss of dental hard tissues caused by non-carious factors, including attrition, abrasion, and erosion, and may present as localised or generalised defects. The 2017 European expert consensus recommends delaying indirect restorative procedures and prioritising minimally invasive, additive approaches. Direct composite veneers represent a conservative and effective option for managing tooth wear, particularly in young patients, individuals with healthy dentition, or those with financial limitations. This case report describes a minimally invasive technique for the management of tooth wear associated with dental erosion and caries using single-shade direct composite veneers, demonstrating functional and aesthetic rehabilitation while preserving tooth structure.
subject: Articles
  topic: section
subject: Errosion, Minimal Invasive Dentistry, Direct composite Resin Restoration, Single Shade Composite Resin.
  topic: keywords
creator: Pradnya V. Bansode
creator: Madhuri Wavdhane
creator: Seema Pathak
creator: Shweta Chavan
rights: Copyright (c) 2026 International Journal of Integrative Dental and Medical Sciences https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-21
publication date: 2026-01-21
starting page: 16
ending page: 19
doi: 10.62896/ijidms.2.1.03

Anterior Diastema Closure Using Frenectomy and Direct Composite Resin Restoration: A Case Report
type: item
description: Midline diastema (MD) is defined as a space greater than 0.5 mm between the proximal surfaces of fully erupted maxillary or mandibular central incisors, with a higher prevalence in the maxillary arch. It is commonly observed during the mixed dentition phase and is considered a normal developmental finding, often closing spontaneously after the eruption of permanent maxillary canines. Persistence of MD into adulthood is usually associated with specific etiological factors such as tooth-size discrepancies, excessive incisal overlap, abnormal incisor angulation, generalized spacing, and aberrant labial frenum attachment. A high or hypertrophic labial frenum with fibers extending into the interdental papilla plays a significant role in the development and maintenance of MD by exerting continuous tensile forces that interfere with space closure and increase the risk of relapse. Therefore, elimination of this etiological factor through frenectomy is often recommended prior to restorative intervention. Management of MD may involve orthodontic, surgical, restorative, or multidisciplinary approaches based on the underlying cause. Diastemas primarily caused by tooth-size discrepancies are particularly suitable for restorative management. Direct composite resin restorations provide a conservative, cost-effective, and aesthetically predictable treatment option, especially with advances in materials and techniques. This case report highlights the importance of performing frenectomy before direct composite resin closure to achieve stable, functional, and aesthetically pleasing outcomes.
subject: Articles
  topic: section
subject: Anterior space closure, Composite resin restoration, Indirect putty, Midline diastema
  topic: keywords
creator: Pradnya Bansode
creator: Seema Pathak
creator: Madhuri Ambhure
creator: Manav Modi
rights: Copyright (c) 2026 International Journal of Integrative Dental and Medical Sciences https://creativecommons.org/licenses/by-nc/4.0
date: 2026-01-20
publication date: 2026-01-20
starting page: 09
ending page: 15
doi: 10.62896/ijidms.2.1.02

MRI Evaluation of Different Types of Cerebral Metastases
type: item
description: Background: Cerebral metastases represent the most common intracranial tumors in adults and are associated with significant morbidity and mortality. Magnetic Resonance Imaging (MRI) is the imaging modality of choice for detection, characterization, and evaluation of brain metastases due to its superior soft-tissue contrast and multiparametric capabilities. Aim: To evaluate the MRI characteristics of different types of cerebral metastases and correlate their imaging features with the primary tumor origin. Materials and Methods: This retrospective descriptive case series included six patients with histopathologically or PET-CT–confirmed primary malignancies and radiologically diagnosed cerebral metastases. All patients underwent brain MRI, including conventional sequences, diffusionweighted imaging, susceptibility-weighted imaging, and MR spectroscopy where applicable. Imaging features such as lesion location, signal characteristics, enhancement patterns, diffusion restriction, hemorrhage, necrosis, and perilesional edema were analyzed. Results: Cerebral metastases demonstrated variable MRI appearances depending on the primary tumor. Lung carcinoma metastases commonly showed cystic lesions with ring enhancement and disproportionate perilesional edema. Hemorrhagic metastases were identified on SWI, particularly in metabolically active lesions. Rare metastatic patterns, such as those from salivary gland tumors, showed extensive multifocal involvement. Diagnostic challenges were encountered in differentiating metastases from primary brain tumors and vascular lesions, especially in cases with mixed solidcystic components. Conclusion: MRI provides critical diagnostic information in the evaluation of cerebral metastases. Recognition of characteristic imaging patterns and their correlation with primary malignancies can improve diagnostic accuracy, aid in differentiation from primary brain tumors, and guide appropriate patient management.
subject: Articles
  topic: section
subject: Cerebral metastases; Magnetic Resonance Imaging; Brain metastasis; Contrast enhancement; Diffusion-weighted imaging; MR spectroscopy
  topic: keywords
creator: Dr. Sangam Gupta
creator: Younus Syed Uz Zaman
creator: Y. P. Sachdev
rights: Copyright (c) 2026
date: 2026-01-18
publication date: 2026-01-18
starting page: 1
ending page: 8
doi: 10.62896/

Orthodontic Treatment and Its Impact on Oral Health–Related Quality of Life
type: item
description: Orthodontic treatment plays a significant role in improving dental alignment, occlusion, facial esthetics, and overall oral function. Beyond clinical outcomes, orthodontic care has a substantial influence on oral health–related quality of life (OHRQoL), which encompasses physical, psychological, and social well-being. Malocclusion can negatively affect mastication, speech, self-esteem, and social interactions, thereby impacting daily life. This manuscript explores the relationship between orthodontic treatment and OHRQoL, highlighting changes experienced by patients before, during, and after treatment. Emphasis is placed on functional improvement, psychosocial benefits, treatment-related discomfort, and long-term patient satisfaction. Understanding the multidimensional effects of orthodontic therapy is essential for patientcentered care, informed consent, and outcome assessment in contemporary orthodontic practice.
subject: Articles
  topic: section
subject: Orthodontic treatment; Oral health–related quality of life; Malocclusion; Patient satisfaction; Psychosocial impact; Dental esthetics
  topic: keywords
creator: Kohinoor Acharya
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 40
ending page: 45
doi: 10.62896/

Phytochemicals in Traditional Medicine: A Modern Approach to Evidence-Based Herbal Therapies
type: item
description: Monkeypox (Mpox), a zoonotic disease caused by the Monkeypox virus (MPXV), has reemerged as a significant global public health challenge. Historically endemic to Central and West Africa, its spread to non-endemic regions during the 2022 outbreak underscored the need for innovative therapeutic and preventive strategies. Traditional Mpox management has relied on repurposed smallpox antivirals and vaccines, such as Tecovirimat and Jynneos, but challenges persist in terms of drug resistance, accessibility, affordability, and vaccine hesitancy. Recent advancements include the development of nextgeneration antivirals, monoclonal antibodies, immunomodulatory therapies, and host-targeted treatments. Emerging technologies like CRISPR gene editing, nanomedicine, and artificial intelligence-driven drug discovery are poised to revolutionize Mpox treatment, offering precision-targeted interventions and enhanced outcomes. Furthermore, public health strategies inspired by smallpox eradication highlight the importance of equitable vaccine distribution, robust surveillance, and international collaboration. Addressing current challenges while leveraging these advancements holds promise for reducing Mpox's burden and preventing future outbreaks. Achieving global eradication will require sustained investment in innovative science, healthcare infrastructure, and global health policies.
subject: Articles
  topic: section
subject: Monkeypox, MPXV, antivirals, vaccines, immunomodulation, CRISPR, nanomedicine, public health.
  topic: keywords
creator: Subham Mandal
creator: Suraj Mandal
creator: Purnima Singh
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 28
ending page: 39
doi: 10.62896/

Phytochemicals in Traditional Medicine: A Modern Approach to Evidence-Based Herbal Therapies
type: item
description: Phytochemicals, bioactive compounds found in plants, have been integral to traditional medicine systems worldwide, including Ayurveda, Traditional Chinese Medicine (TCM), and Indigenous healing practices. With the rise of modern scientific methodologies, there is an increasing emphasis on validating the therapeutic potential of these plant-derived compounds through evidence-based approaches. This paper explores the role of phytochemicals in traditional medicine, highlighting their pharmacological properties, mechanisms of action, and clinical applications. A comparative analysis of conventional herbal therapies and their integration into modern medicine is presented, emphasizing advancements in analytical techniques, clinical trials, and regulatory frameworks. The study also addresses challenges such as standardization, bioavailability, and potential toxicity, underscoring the need for rigorous scientific validation. By bridging the gap between traditional knowledge and modern research, this paper aims to promote the safe and effective use of phytochemicals in contemporary healthcare.
subject: Articles
  topic: section
subject: Phytochemicals, Traditional Medicine, Herbal Therapies, Evidence-Based Medicine, Pharmacology, Clinical Validation
  topic: keywords
creator: Subham Mandal
creator: Suraj Mandal
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 18
ending page: 27
doi: 10.62896/

Comparative Evaluation of Analgesic, Anti-Inflammatory, and Antipyretic Activities of Morus alba and Pyrus pyrifolia
type: item
description: Herbal remedies have historically served as a fundamental aspect of conventional healing methods across the globe, with Morus alba (Mulberry) and Pyrus pyrifolia (Asian Pear) standing out as significant botanicals in Eastern medicinal practices. The objective of this research is to evaluate and contrast their medicinal characteristics, with particular emphasis on their pain-relieving, inflammation-reducing, and feverreducing effects. Morus alba boasts a wealth of flavonoids, anthocyanins, and resveratrol, whereas Pyrus pyrifolia is abundant in phenolic compounds, flavonoids, and tannins, all recognised for their beneficial antioxidant and anti-inflammatory effects. Both botanical specimens exhibit encouraging capabilities in mitigating discomfort and swelling, with Morus alba showcasing superior effectiveness in a range of assessments, such as the tail-flick test, formalin-induced pain evaluation, carrageenan-induced paw oedema analysis, and Brewer’s yeast-induced fever experiments. Moreover, both species demonstrate a slight level of toxicity, indicating a potentially advantageous safety profile for medicinal applications. The results indicate the promising capabilities of Morus alba and Pyrus pyrifolia as natural options for alleviating pain, reducing inflammation, and lowering fever, thereby encouraging additional clinical investigations to uncover their complete therapeutic benefits.
subject: Articles
  topic: section
subject: Herbal Medicine, Morus alba, Pyrus pyrifolia, Analgesic Properties, Anti-inflammatory Effects
  topic: keywords
creator: Suraj Mandal
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 7
ending page: 17
doi: 10.62896/

Transforming Oral Healthcare Through AI: A White Paper on SwaLife Oral Disease Diagnosis
type: item
description: Artificial intelligence (AI) is rapidly transforming healthcare by enabling early detection, accurate diagnosis, and personalized treatment planning. In dentistry, AI-driven technologies are emerging as powerful tools forimproving the diagnosis and management of oral diseases. This white paper presents SwaLife Oral Disease Diagnosis, an AI-enabled platform designed to enhance oral healthcare through intelligent analysis of clinical data, dental images, and patient-specific information. By integrating machine learning algorithms with dental expertise, the system supports early identification of oral pathologies, risk assessment, and decision support for clinicians. The application of AI in oral disease diagnosis has the potential to improve diagnostic accuracy, reduce variability, optimize clinical workflows, and promote preventive care. This white paper highlights the role of AI-powered solutions in advancing precision dentistry and shaping the future of oral healthcare delivery.
subject: Articles
  topic: section
subject: Artificial intelligence; Oral healthcare; Dental diagnostics; Oral disease detection; Machine learning; Precision dentistry; SwaLife
  topic: keywords
creator: Pravin Badhe
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 6
doi: 10.62896/

Oxidative Stress and Reactive Oxygen Species in Tumor Initiation and Progression
type: item
description: Oxidative stress and reactive oxygen species (ROS) have gained significant attention as key players in the initiation and progression of various cancers. The imbalance between ROS production and the body's antioxidant defenses creates a cellular environment conducive to genetic mutations, inflammation, and alterations in cellular signaling pathways. This paper explores the role of oxidative stress and ROS in tumorigenesis, examining how they contribute to DNA damage, genomic instability, and the activation of oncogenes. Moreover, we discuss the complex relationship between ROS and tumor progression, emphasizing their influence on angiogenesis, metastasis, and resistance to therapy. Furthermore, the potential of antioxidant strategies and ROS-targeting therapies for cancer prevention and treatment are explored. This review highlights the necessity of understanding the molecular mechanisms through which oxidative stress and ROS influence cancer development, with the goal of identifying novel therapeutic targets and improving clinical outcomes.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Oxidative stress, Reactive oxygen species, Tumor initiation, Tumor progression, Cancer, DNA damage, Genomic instability, Oncogenes, Angiogenesis, Metastasis, Antioxidants, Cancer therapy, Tumor microenvironment
creator: Ruchismita Manna
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 32
ending page: 38
doi: 10.62896/

The Emerging Role of Non-Coding RNAs in Carcinogenesis and Tumor Metastasis
type: item
description: Non-coding RNAs (ncRNAs) have emerged as crucial regulators of cellular processes, including gene expression, chromatin remodeling, and cellular signaling. Recent advancements in molecular biology have uncovered their pivotal role in carcinogenesis and tumor metastasis. These ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), regulate a variety of biological pathways that govern tumor initiation, progression, and spread to distant organs. miRNAs are involved in post-transcriptional regulation and can act as either tumor suppressors or oncogenes, depending on the target genes they regulate. lncRNAs contribute to the formation of complex molecular networks that modulate tumor cell proliferation, apoptosis, and migration. Furthermore, circRNAs, with their unique stable structure, are being recognized as key regulators of metastasisrelated pathways. The dysregulation of these ncRNAs in cancerous cells highlights their potential as biomarkers for early diagnosis and therapeutic targets. Understanding the role of ncRNAs in carcinogenesis and metastasis is crucial for the development of novel diagnostic and therapeutic strategies, offering hope for more effective cancer treatments in the future.
subject: Articles
  topic: section
subject: Non-coding RNAs, carcinogenesis, tumor metastasis, microRNAs, long non-coding RNAs, circular RNAs, cancer progression, biomarkers, gene regulation, therapeutic targets.
  topic: keywords
creator: Nripendra Singh
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 24
ending page: 31
doi: 10.62896/

Molecular Crosstalk Between Chronic Inflammation and Cancer Development
type: item
description: Chronic inflammation is increasingly recognized as a critical driver of cancer development, contributing to tumor initiation, progression, and metastasis. The molecular crosstalk between chronic inflammation and cancer involves complex signaling networks that alter cellular behavior and the tumor microenvironment. Inflammatory mediators, such as cytokines, chemokines, and growth factors, activate signaling pathways like NF-κB, JAK-STAT, and MAPK, which promote cell proliferation, survival, angiogenesis, and immune evasion. Additionally, chronic inflammation leads to the accumulation of reactive oxygen and nitrogen species, which induce DNA damage, further driving genomic instability. This paper explores the molecular mechanisms underlying the inflammatory response in cancer, focusing on the bidirectional interaction between immune cells and cancer cells. By examining key signaling molecules, transcription factors, and immune modulators involved in this crosstalk, the paper highlights potential therapeutic targets aimed at disrupting the inflammatory pathways that fuel carcinogenesis. Understanding the intricate relationship between chronic inflammation and cancer is crucial for the development of novel preventive and therapeutic strategies to combat inflammation-driven cancers.
subject: Articles
  topic: section
subject:
  topic: keywords
  value: Chronic inflammation, cancer development, molecular crosstalk, tumor initiation, tumor progression, signaling pathways, NFκB, JAK-STAT, MAPK, cytokines, chemokines, growth factors, reactive oxygen species, DNA damage, genomic instability, immune evasion, tumor microenvironment
creator: Sravani Boyapati
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 16
ending page: 23
doi: 10.62896/

Oncogenic Signaling Pathways in Tumor Progression: An Update on PI3K/AKT/MTOR and MAPK axis
type: item
description: Oncogenic signaling pathways play a crucial role in the initiation, progression, and metastasis of various cancers. Among these, the PI3K/AKT/mTOR and MAPK signaling axes are frequently implicated in tumorigenesis and are considered key drivers of tumor cell survival, proliferation, and resistance to therapy. The PI3K/AKT/mTOR pathway regulates cellular processes such as growth, metabolism, and survival, while the MAPK pathway, comprising multiple kinases like ERK, JNK, and p38, is involved in cell differentiation, migration, and stress responses. Dysregulation of these pathways often results in uncontrolled cellular proliferation and metastasis. Recent advances in understanding the molecular mechanisms underlying these signaling pathways have led to the development of targeted therapies aimed at inhibiting specific components within these pathways. This paper provides a comprehensive update on the role of the PI3K/AKT/mTOR and MAPK axes in tumor progression, focusing on their molecular interactions, functional implications in cancer, and the emerging therapeutic strategies targeting these pathways. Understanding these signaling networks is critical for developing more effective treatments for cancer patients.
subject: Articles
  topic: section
subject: Oncogenic signaling, PI3K/AKT/mTOR pathway, MAPK pathway, tumor progression, cancer therapy, molecular mechanisms, targeted therapies, cellular proliferation, metastasis, kinase inhibitors.
  topic: keywords
creator: Savita Sambhaji Patil
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 8
ending page: 15
doi: 10.62896/

Epigenetic Alterations in Carcinogenesis: Role of DNA Methylation and Histone Modifications
type: item
description: Epigenetic alterations, particularly DNA methylation and histone modifications, play a crucial role in the initiation, progression, and metastasis of cancer. Unlike genetic mutations, which involve changes in the DNA sequence, epigenetic modifications are reversible and can be influenced by environmental factors, lifestyle, and age. DNA methylation, the addition of a methyl group to the 5’ position of cytosine residues, typically leads to gene silencing and has been associated with the inactivation of tumor suppressor genes. On the other hand, histone modifications, including acetylation, methylation, and phosphorylation, influence chromatin structure and gene expression. These modifications can either promote or inhibit the expression of oncogenes and tumor suppressor genes, depending on the specific modification and context. This paper reviews the roles of DNA methylation and histone modifications in carcinogenesis, exploring their impact on gene expression regulation, tumor progression, and potential for therapeutic intervention. A comprehensive understanding of these epigenetic mechanisms may open new avenues for early detection, targeted therapy, and the development of epigenetic drugs in cancer treatment.
subject: Articles
  topic: section
subject: Epigenetics, Carcinogenesis, DNA Methylation, Histone Modifications, Gene Expression, Tumor Suppressor Genes, Oncogenes, Chromatin, Cancer Therapy
  topic: keywords
creator: Shivanand Kolageri
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 7
doi: 10.62896/

Obesity-Linked Metabolic Alterations as Drivers of Carcinogenesis
type: item
description: Obesity has become a global health epidemic, and growing evidence suggests that it plays a significant role in the development and progression of various types of cancer. This paper explores the metabolic alterations associated with obesity that contribute to carcinogenesis, focusing on changes in adipose tissue, insulin resistance, inflammatory pathways, and altered hormone regulation. The accumulation of excess fat, particularly visceral fat, leads to chronic low-grade inflammation, dysregulated adipokine secretion, and enhanced growth factor signaling, all of which can promote tumor initiation and progression. Additionally, the paper discusses the impact of obesity on the tumor microenvironment, immune evasion, and angiogenesis. Understanding these obesity-linked metabolic alterations provides valuable insights into potential therapeutic strategies for preventing or treating cancer in obese individuals. The aim of this research is to underline the importance of addressing obesity as a modifiable risk factor in cancer prevention and to highlight the complex interplay between metabolic dysfunction and cancer biology
subject: Articles
  topic: section
subject: obesity, carcinogenesis, metabolic alterations, adipose tissue, insulin resistance, inflammation, adipokines, tumor microenvironment, immune evasion, angiogenesis, cancer prevention.
  topic: keywords
creator: Arindam Kolay
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 27
ending page: 33
doi: 10.62896/

Dietary Polyphenols and their Protective Role Against Carcinogenesis
type: item
description: Dietary polyphenols, a diverse group of bioactive compounds found in fruits, vegetables, grains, and beverages like tea and wine, have gained considerable attention for their potential to prevent cancer. This paper explores the protective role of polyphenols against carcinogenesis, examining their mechanisms of action, including antioxidant activity, modulation of cell signaling pathways, regulation of gene expression, and inhibition of inflammation. Through a review of experimental studies and clinical trials, the research highlights how polyphenols can interfere with various stages of cancer development, such as initiation, promotion, and progression. The paper further discusses the bioavailability and metabolism of polyphenols, which may influence their efficacy in cancer prevention. Despite challenges in translating preclinical findings into clinical practice, the existing evidence supports the notion that a polyphenol-rich diet may reduce the risk of certain types of cancer.
subject: Articles
  topic: section
subject: Polyphenols, carcinogenesis, cancer prevention, antioxidants, bioavailability, inflammation, cell signaling, gene expression, dietary factors.
  topic: keywords
creator: Jayesh Baldota
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 14
ending page: 20
doi: 10.62896/

Minimally Invasive Techniques in Oral and Maxillofacial Surgery
type: item
description: Minimally invasive techniques have transformed the field of oral and maxillofacial surgery by reducing surgical trauma, enhancing precision, and improving patient-centered outcomes. These approaches aim to achieve optimal therapeutic results while minimizing tissue damage, postoperative pain, complications, and recovery time. Advances in imaging, instrumentation, endoscopic assistance, and digital planning have expanded the scope of minimally invasive procedures in the management of dentoalveolar conditions, maxillofacial trauma, temporomandibular joint disorders, and reconstructive surgery. This manuscript provides a comprehensive overview of minimally invasive techniques in oral and maxillofacial surgery, highlighting their principles, clinical applications, benefits, limitations, and future directions. The integration of these techniques into routine practice represents a significant step toward safer, more efficient, and patientfriendly surgical care.
subject: Articles
  topic: section
subject: Minimally invasive surgery; Oral and maxillofacial surgery; Endoscopic techniques; Digital planning; Patient-centered care; Surgical innovation
  topic: keywords
creator: Kiran Srinivas B
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 9
ending page: 13
doi: 10.62896/

Advances in Maxillofacial Trauma Management and Rehabilitation
type: item
description: Maxillofacial trauma represents a significant clinical challenge due to its complex anatomical involvement, functional implications, and psychosocial impact on patients. Injuries to the facial skeleton and associated soft tissues often result from road traffic accidents, interpersonal violence, falls, and sports-related incidents. Advances in maxillofacial trauma management have led to improved diagnostic accuracy, surgical precision, and rehabilitation outcomes. This manuscript provides a comprehensive overview of contemporary advances in the assessment, management, and rehabilitation of maxillofacial trauma. Emphasis is placed on modern imaging techniques, surgical approaches, fixation systems, multidisciplinary care, and rehabilitative strategies aimed at restoring function, esthetics, and quality of life. The integration of innovative technologies and patient-centered rehabilitation protocols has significantly enhanced clinical outcomes and long-term recovery in maxillofacial trauma patients.
subject: Articles
  topic: section
subject: Maxillofacial trauma; Facial fractures; Trauma management; Surgical fixation; Rehabilitation; Functional recovery; Oral and maxillofacial surgery
  topic: keywords
creator: Dishant Kumar Sonpal
rights: Copyright (c) 2025
date: 2025-08-28
publication date: 2025-08-28
starting page: 4
ending page: 8
doi: 10.62896/

Clinical Outcomes of Oral and Maxillofacial Surgical Interventions: A Retrospective Study
type: item
description: Oral and maxillofacial surgery plays a critical role in the diagnosis and management of a wide range of conditions affecting the oral cavity, jaws, face, and associated structures. Evaluating clinical outcomes of surgical interventions is essential for improving patient care, surgical planning, and long-term prognosis. This retrospective study analyzes the clinical outcomes of various oral and maxillofacial surgical procedures performed over a defined period, focusing on treatment success, postoperative complications, and patient recovery. The findings highlight the effectiveness of contemporary surgical techniques, the influence of patient-related factors, and the importance of comprehensive preoperative assessment and postoperative care. The study underscores the value of outcome-based evaluation in enhancing surgical quality and optimizing patient-centered care in oral and maxillofacial surgery.
subject: Articles
  topic: section
subject: Oral and maxillofacial surgery; Clinical outcomes; Retrospective study; Surgical interventions; Postoperative complications; Patient recovery
  topic: keywords
creator: Kohinoor Acharya
rights: Copyright (c) 2025
date: 2026-01-09
publication date: 2026-01-09
starting page: 1
ending page: 3
doi: 10.62896/

Oral Health Awareness and Its Role in Public Health Promotion
type: item
description: Oral health is an essential component of overall health and well-being, yet it is often neglected in public health planning and individual health practices. Oral diseases such as dental caries, periodontal diseases, and oral infections remain highly prevalent and largely preventable. Oral health awareness plays a critical role in reducing the burden of these conditions and promoting healthier communities. This manuscript explores the significance of oral health awareness in public health promotion, highlighting its impact on disease prevention, health behavior modification, and quality of life. It discusses the relationship between oral health and systemic health, the importance of education and community engagement, and the role of healthcare professionals and policymakers in advancing oral health awareness. Strengthening oral health awareness through integrated public health strategies can contribute to improved health outcomes and reduced healthcare disparities.
subject: Articles
  topic: section
subject: Oral health awareness; Public health promotion; Preventive dentistry; Health education; Community health; Oral-systemic health; Health behavior
  topic: keywords
creator: Pavan Kumar Koralakunte Ravi
rights: Copyright (c) 2025
date: 2025-05-21
publication date: 2025-05-21
starting page: 21
ending page: 25
doi: 10.62896/

Innovations in Restorative Dentistry: Materials, Techniques, and Clinical Outcomes
type: item
description: Restorative dentistry has undergone significant transformation with the introduction of advanced materials, innovative techniques, and digital technologies aimed at improving clinical outcomes and patient satisfaction. Modern restorative approaches emphasize minimally invasive procedures, esthetics, durability, and biological compatibility while preserving natural tooth structure. This manuscript explores recent innovations in restorative dentistry, focusing on contemporary restorative materials, evolving clinical techniques, and their impact on functional and esthetic outcomes. It discusses advances in composite resins, ceramics, bioactive materials, adhesive systems, and digital workflows, along with their clinical applications. Emphasis is placed on evidenceinformed decision-making, patient-centered care, and long-term restoration success. These innovations collectively contribute to enhanced oral health, improved quality of life, and sustainable restorative dental practices.
subject: Articles
  topic: section
subject: Restorative dentistry; Dental materials; Composite resins; Dental ceramics; Adhesive systems; Digital dentistry; Clinical outcomes
  topic: keywords
creator: Abhijeet Humne
rights: Copyright (c) 2025
date: 2025-05-21
publication date: 2025-05-21
starting page: 16
ending page: 20
doi: 10.62896/

Impact of Oral Hygiene Practices on Systemic Health Outcomes
type: item
description: Oral hygiene practices are fundamental to maintaining oral health, yet growing evidence suggests their influence extends far beyond the oral cavity. Poor oral hygiene contributes to the development of periodontal diseases and chronic oral infections, which may serve as sources of systemic inflammation and microbial dissemination. This manuscript examines the impact of oral hygiene practices on systemic health outcomes, emphasizing biological mechanisms, clinical associations, and preventive strategies. It explores the role of oral biofilm control in reducing systemic disease risk, highlights connections between oral health and cardiovascular diseases, diabetes, respiratory conditions, adverse pregnancy outcomes, and overall immune function. The paper underscores the importance of integrated dental–medical care and patient education in promoting holistic health and improving long-term health outcomes.
subject: Articles
  topic: section
subject: Oral hygiene; Systemic health; Periodontal disease; Inflammation; Oral-systemic link; Preventive care; Integrated healthcare
  topic: keywords
creator: Mohit MP
rights: Copyright (c) 2026
date: 2025-05-21
publication date: 2025-05-21
starting page: 11
ending page: 15
doi: 10.62896/

Dental Caries and Periodontal Diseases: An Integrative Clinical Perspective
type: item
description: Dental caries and periodontal diseases are the two most prevalent oral health conditions affecting populations worldwide and remain leading causes of tooth loss and compromised quality of life. Traditionally viewed as distinct pathological entities, growing clinical and biological evidence highlights significant interrelationships between these diseases. This manuscript presents an integrative clinical perspective on dental caries and periodontal diseases, emphasizing shared etiological factors, overlapping risk determinants, and coordinated preventive and therapeutic strategies. The paper discusses the microbial, behavioral, systemic, and environmental influences contributing to disease progression, along with modern diagnostic approaches and patientcentered management. By integrating preventive dentistry, periodontal therapy, restorative care, and behavioral interventions, clinicians can improve long-term oral and systemic health outcomes. This holistic approach supports comprehensive oral healthcare that aligns with contemporary clinical practice and public health goals.
subject: Articles
  topic: section
subject: Dental caries; Periodontal disease; Oral health; Integrative dentistry; Plaque biofilm; Preventive care; Clinical management
  topic: keywords
creator: Greeshma K
rights: Copyright (c) 2025
date: 2025-05-21
publication date: 2025-05-21
starting page: 6
ending page: 10
doi: 10.62896/

Advances in Preventive Dentistry: Clinical Strategies for Long-Term Oral Health
type: item
description: Preventive dentistry has emerged as a cornerstone of modern oral healthcare, focusing on the prevention of oral diseases rather than their treatment at advanced stages. With increasing awareness of the link between oral health and systemic well-being, preventive strategies have evolved to incorporate evidence-based clinical practices, patientcentered care, and innovative technologies. This manuscript explores recent advances in preventive dentistry, highlighting contemporary clinical strategies aimed at achieving long-term oral health. Key areas discussed include risk assessment, oral hygiene practices, fluoride therapy, dietary counseling, minimally invasive dentistry, behavioral interventions, and the integration of digital tools in preventive care. Emphasis is placed on individualized prevention plans, early disease detection, and interdisciplinary collaboration. By adopting comprehensive preventive approaches, dental professionals can significantly reduce the burden of oral diseases, enhance patient quality of life, and promote sustainable oral healthcare outcomes.
subject: Articles
  topic: section
subject: Preventive dentistry; Oral health promotion; Dental caries prevention; Periodontal disease; Fluoride therapy; Risk assessment; Minimally invasive dentistry
  topic: keywords
creator: Swesha Chhabra
rights: Copyright (c) 2026
date: 2025-05-21
publication date: 2025-05-21
starting page: 1
ending page: 5
doi: 10.62896/

The Role of Oral Microbiota in Systemic Diseases: Bridging the gap between Dentistry and Medicine
type: item
description: Oral microbiota, a diverse community of microorganisms residing in the oral cavity, plays a crucial role in maintaining oral and systemic health. Recent research highlights the intricate link between oral microbiota and various systemic diseases, including cardiovascular disease, diabetes, respiratory infections, rheumatoid arthritis, and neurological disorders. Dysbiosis, an imbalance in microbial composition, can lead to periodontal disease, which acts as a reservoir of inflammation and pathogenic bacteria, exacerbating systemic conditions. The bidirectional relationship between oral health and systemic diseases underscores the need for interdisciplinary collaboration between dentistry and medicine. This paper explores the mechanisms through which oral microbiota influences systemic health, examines key microbial pathogens involved in disease progression, and discusses emerging diagnostic and therapeutic strategies aimed at leveraging oral microbiota for disease prevention and treatment. Bridging the gap between dentistry and medicine through a holistic approach to patient care can enhance early detection, personalized treatment, and overall health outcomes.
subject: Articles
  topic: section
subject: Oral microbiota, Systemic diseases, Dysbiosis, Periodontal disease, Inflammation, Cardiovascular disease, Diabetes, Respiratory infections
  topic: keywords
creator: Atika Ismail
creator: Pavan Kumar K R
creator: Suraj Mandal
rights: Copyright (c) 2025
date: 2025-03-17
publication date: 2025-03-17
starting page: 30
ending page: 36
doi: 10.62896/

Psychological Well-Being and Oral Health: The Role of Dentistry in Comprehensive Healthcare
type: item
description: Oral health plays a crucial role in overall well-being, influencing both physical and psychological health. Poor oral hygiene and dental diseases are not only linked to systemic health conditions but also significantly impact an individual's self-esteem, social interactions, and mental health. This paper explores the intricate relationship between psychological well-being and oral health, emphasizing the role of dentistry in comprehensive healthcare. The study highlights how dental conditions such as tooth loss, malocclusion, and periodontal diseases contribute to stress, anxiety, and depression. Furthermore, it examines the psychological effects of dental treatments and aesthetic dentistry in restoring confidence and improving quality of life. Through a review of current literature and clinical studies, this research underscores the need for an integrated healthcare approach where dentistry collaborates with mental health professionals to provide holistic patient care. By addressing both the physical and psychological aspects of oral health, dentistry can play a transformative role in enhancing overall health outcomes. The study concludes with recommendations for interdisciplinary strategies to bridge the gap between oral health and mental well-being, advocating for policies that promote awareness, accessibility, and mental health support in dental care settings.
subject: Articles
  topic: section
subject: Oral Health, Psychological Well-being, Dentistry, Mental Health, Comprehensive Healthcare, Aesthetic Dentistry, Interdisciplinary Approach
  topic: keywords
creator: Monisha R
creator: Kartik Yadav
creator: Subham Mandal
creator: Suraj Mandal
rights: Copyright (c) 2025
date: 2025-03-17
publication date: 2025-03-17
starting page: 22
ending page: 29
doi: 10.62896/

Interdisciplinary Approaches to Managing Oral Cancer: Combining Dentistry, Oncology, and Surgery
type: item
description: Oral cancer presents a significant global health challenge, necessitating a multidisciplinary approach for effective management. This paper explores the integration of dentistry, oncology, and surgery in the diagnosis, treatment, and post-treatment rehabilitation of oral cancer patients. Early detection by dental professionals plays a crucial role in improving prognosis, while oncologists contribute to targeted therapies such as chemotherapy, immunotherapy, and radiation therapy. Surgical interventions, including tumor resection and reconstructive procedures, restore functionality and aesthetics. The collaboration among these disciplines enhances patient outcomes by ensuring comprehensive care, minimizing recurrence rates, and improving the quality of life. Challenges such as treatment delays, accessibility to specialized care, and the need for personalized treatment strategies are also discussed. The study highlights the importance of a holistic, patient-centered approach that integrates advancements in medical research, technology, and clinical expertise to optimize oral cancer management.
subject: Articles
  topic: section
subject: Oral Cancer, Interdisciplinary Approach, Dentistry, Oncology, Surgery, Multidisciplinary Treatment, Patient-Centered Care
  topic: keywords
creator: Madhumitha
creator: Ponmari K
creator: Aakash Kumar Jaiswal
creator: K. Arun Chand Roby
rights: Copyright (c) 2025
date: 2025-03-17
publication date: 2025-03-17
starting page: 15
ending page: 21
doi: 10.62896/

Integrative Pain Management: Dental and Medical Strategies in the Treatment of Temporomandibular Joint Disorder
type: item
description: Temporomandibular Joint Disorder (TMD) is a complex condition affecting the jaw joint and surrounding muscles, leading to chronic pain and functional impairments. Traditional treatment approaches have largely focused on either dental or medical interventions, often leading to limited success in long-term pain management. This paper explores an integrative pain management model that combines dental and medical strategies to improve patient outcomes. Key approaches include occlusal therapy, orthodontic interventions, physical therapy, pharmacological management, minimally invasive procedures, and behavioral therapies. The role of patient-centered care, multidisciplinary collaboration, and the incorporation of emerging techniques such as regenerative medicine and neuromodulation are also discussed. By addressing the multifactorial nature of TMD through a holistic and evidence-based approach, integrative pain management provides a promising avenue for enhancing treatment efficacy and improving patients' quality of life.
subject: Articles
  topic: section
subject: Temporomandibular Joint Disorder, Integrative Pain Management, Occlusal Therapy, Pharmacological Treatment, Regenerative Medicine, Multidisciplinary Approach.
  topic: keywords
creator: Kishorwara Ramamoorthy
creator: Mridali Mehta
creator: Satender Khatri
creator: Vinay S
rights: Copyright (c) 2025
date: 2025-03-17
publication date: 2025-03-17
starting page: 7
ending page: 14
doi: 10.62896/

Advances in Dental Biomaterials: Bridging Dentistry and Medicine for Improved Patient Outcomes
type: item
description: The field of dental biomaterials has undergone significant advancements, bridging the gap between dentistry and medicine to enhance patient outcomes. Modern biomaterials, including bioactive ceramics, nanocomposites, and regenerative scaffolds, have revolutionized dental treatments by improving biocompatibility, durability, and functionality. Innovations in tissue engineering, such as stem cell applications and 3Dprinted biomaterials, have further enhanced periodontal regeneration and implant integration. Additionally, interdisciplinary research in biomaterials science has led to the development of smart materials with antibacterial properties, minimizing post-treatment complications. This paper explores the latest advancements in dental biomaterials, their medical implications, and their role in personalized dentistry. The integration of biocompatible and regenerative materials not only improves oral health but also contributes to systemic health, highlighting the convergence of dentistry and medicine. Future research directions and challenges in clinical translation are also discussed to provide insights into the evolving landscape of dental biomaterials.
subject: Articles
  topic: section
subject: Dental biomaterials, biocompatibility, regenerative dentistry, nanotechnology, smart materials, personalized dentistry.
  topic: keywords
creator: Soumik Chatterjee
creator: I. Niyas Ahamed
creator: Mansi Aggarwal
creator: Subham Mandal
creator: Suraj Mandal
rights: Copyright (c) 2025
date: 2025-03-17
publication date: 2025-03-17
starting page: 1
ending page: 6
doi: 10.62896/ijidms.v1.i1.01