Comparative Evaluation of Analgesic, Anti-Inflammatory, and Antipyretic Activities of Morus alba and Pyrus pyrifolia

Abstract

Herbal remedies have historically served as a fundamental aspect of conventional healing methods across the globe, with Morus alba (Mulberry) and Pyrus pyrifolia (Asian Pear) standing out as significant botanicals in Eastern medicinal practices. The objective of this research is to evaluate and contrast their medicinal characteristics, with particular emphasis on their pain-relieving, inflammation-reducing, and feverreducing effects. Morus alba boasts a wealth of flavonoids, anthocyanins, and resveratrol, whereas Pyrus pyrifolia is abundant in phenolic compounds, flavonoids, and tannins, all recognised for their beneficial antioxidant and anti-inflammatory effects. Both botanical specimens exhibit encouraging capabilities in mitigating discomfort and swelling, with Morus alba showcasing superior effectiveness in a range of assessments, such as the tail-flick test, formalin-induced pain evaluation, carrageenan-induced paw oedema analysis, and Brewer’s yeast-induced fever experiments. Moreover, both species demonstrate a slight level of toxicity, indicating a potentially advantageous safety profile for medicinal applications. The results indicate the promising capabilities of Morus alba and Pyrus pyrifolia as natural options for alleviating pain, reducing inflammation, and lowering fever, thereby encouraging additional clinical investigations to uncover their complete therapeutic benefits.